Prof.dr.ir Jaap Keijer is a molecular physiologist and an expert in the molecular response analysis of dietary intervention studies, in vivo, in humans and rodents, and in vitro. His focus is on energy homeostasis and how this is affected by energy status and can be mosdulated by bioactive food components. He has extensively applied profiling techniques (whole genome transcriptome analysis and plasma protein multiplexing) in (collaborative) projects addressing the physiology of adipose tissue, but also lung and more recently, mammary tissue. He has published over 80 international peer reviewed publications and coordinates EC Cost Action FA0602 Mitofood (bioactive food components, mitochondrial function and human health).

Publications:

• Keijer J, Van Schothorst EM (2008). Adipose tissue failure and mitochondria as a possible target for improvement by bioactive food components. Current Opinion in Lipidology, 19:4-1
• Wang P, Mariman E, Renes J, Keijer J (2008) The secretory function of adipocytes in the physiology of white adipose tissue. The Journal of Cellular Physiology, 216: 3-13.
• Rodenburg W, Heidema AG, Boer JAM, Bovee-Oudenhoven IMJ, Feskens EJM, Mariman ECM, Keijer J (2008) A framework for identification of physiological responses in microarray based gene expression studies: selection and interpretation of biologically relevant genes. Physiological Genomics. 33:78-90
• Van Schothorst EM, Bunschoten A, Schrauwen P, Mensink RP, Keijer J (2009) Effects of a high fat, low versus high glycemic index diet: retardation of insulin resistance involves adipose tissue modulation. FASEB J 23:1092-1101.
• Van Schothorst EM, Flachs P, Franssen-van Hal NLW, Kuda O, Bunschoten JE, Molthoff J, Vink C, Hooiveld GJEJ, Kopecky J, Keijer J (2009) Induction of lipid oxidation genes by polyunsaturated fatty acids of marine origin in small intestine of mice fed a high-fat diet. BMC genomics, 10:110.