Human and Animal Physiology Chairgroup of the Animal Sciences Wageningen University aims to understand body functions by studying the underlying mechanisms. We focus on how energy metabolism is related to health. We do this by parallel analysis of cell, tissue and whole body energy metabolism and the molecular processes that occur under different conditions. Interactive effects are studied of nutrients, focusing on micronutrients and secondary plant metabolites, and of physiological conditions. The physiological conditions examined are body energy status (lean vs obese, positive vs negative energy balance) and activity (sedentary vs active) and other interventions that modulate energy metabolism or energy homeostasis (oxygen sufficient vs oxygen limited, high vs low glycemic load). With sexe taken into account.
The objective of our studies is to understand metabolic health, metabolic strength and metabolic adaptation. We design our studies to deliver:
- Biomarkers, to examine health effects of nutrients
- Key regulators, as targets for interventions
- Health beneficial effects of nutrients
- Insight in thresholds for nutritional requirements
- Strategies for metabolic interventions for healthy aging and healthy animal production and against obesity.
We address questions in humans and (production) animals. To answer the questions we use rodent models, with validation in humans and animals. We use state-of-the-art tools to assess whole body physiology, to examine the function of cells and mitochondria and to analyze the function and expression of genes and proteins. Human and animal physiology is fully embedded in Animal Sciences at Wageningen University.